Type 2 diabetes gene TCF7L2polymorphism is not associated with fetal and postnatal growth in two birth cohort studies

Table 4 Birth characteristics in both cohorts according to TCF7L2 rs7903146 genotype of child.

Generation R		CC (n = 1762)	CT (n = 1351)	TT (n = 306)	p-value^#
Gestational age (weeks)	n = 3419	40.3 (36.7 – 42.3)	40.3 (36.6 – 42.4)	40.1 (37.1 – 42.6)	0.83
Birth head circumference (SDS)*	n = 2314	0.22 (0.9)	0.24 (0.9)	0.26 (0.9)	0.55
Birth length (SDS)*	n = 1959	-0.07 (1.0)	-0.08 (1.0)	0.00 (1.1)	0.66
Birth weight (SDS)	n = 3419	0.21 (1.0)	0.22 (1.0)	0.20 (1.0)	0.97
SGA Cohort		CC (n = 270)	CT (n = 255)	TT (n = 41)	p-value ^#
Gestational age (weeks)	n = 566	38.0 (28.6 – 42.0)	38.0 (28.6 – 41.0)	38.0 (29.0 – 42.0)	0.57
Birth head circumference (SDS)	n = 203	-1.51 (1.4)	-1.20 (1.6)	-1.31 (1.4)	0.32
Birth length (SDS)	n = 491	-3.11 (1.4)	-3.27 (1.5)	-3.02 (1.5)	0.41
Birth weight (SDS)	n = 566	-2.40 (1.0)	-2.46 (0.9)	-2.32 (0.9)	0.58

* Length and head circumference were measured in the first two months of after birth.
Values are means (SD) or medians (95% range). SDS = standard deviation score for age and gender.
^# p-values for additive models. Differences were tested using linear regression analyses.

ISSN: 1471-2350