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Table 2 Association of BMI with two SNPs

From: Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI

GLM analysisa

SNP

    

P value

rs11575892

Genotype

C/C

C/T

T/T

0.001

 

Number

1101

34

-

 
 

Mean logBMI ± SE

1.446 ± 0.005

1.491 ± 0.014

-

 
 

(95% CI)

(1.436–1.456)

(1.463–1.518)

-

 
 

Mean BMIc (kg/m2)

27.92

30.97

-

 

rs5030980

Genotype

G/G

G/A

A/A

0.986

 

Number

720

68

1

 
 

Mean logBMI ± SE

1.458 ± 0.007

1.458 ± 0.011

1.471 ± 0.076

 
 

(95% CI)

(1.445–1.472)

(1.436–1.481)

(1.322–1.620)

 
 

Mean BMIc (kg/m2)

28.70

28.70

29.58

 

Categorical analysis b

SNP

 

Genotype distribution (n)

 

OR (95% CI)

P value

  

BMI <= median

BMI > median

  

rs11575892

C/C

558

543

2.59 (1.24–5.37)

0.011

 

C/T

12

22

  

rs5030980

G/G

368

352

1.08 (0.65–1.78)

0.767

 

G/A

33

35

  
 

A/A

0

1

  
  1. SE, standard error of mean; CI, confidence interval; OR, odds ratio.
  2. a- values from general linear model adjusted for gender, age, presence of hypertension, angina pectoris, myocardial infarction, heart failure and T2DM
  3. b- values from logistic regression adjusted for age and gender
  4. c- BMI values back-transformed from mean logBMI values