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Table 4 GOminer gene ontology analysis of GWAS results, indicating the most over-represented ontological categories.

From: An Open Access Database of Genome-wide Association Results

 

Including WTCCC/DGI results (n = 5966 genes)

Excluding WTCCC/DGI results (n = 2888 genes)

Gene Ontology category

RefSeq genes in Category

RefSeq genes observed in GWAS

GO category enrichment

P-value for enrichment

FDR

P-value for enrichment

GO:0007155_cell_adhesion

650

309

1.41

4.56E-14

0

1.99E-17

GO:0051056_regulation_of_small_GTPase_mediated_signal_transduction

161

94

1.73

9.73E-11

0

3.76E-06

GO:0051179_localization

2493

975

1.16

1.12E-10

0

2.32E-07

GO:0006810_transport

2128

837

1.17

1.13E-09

0

2.46E-06

GO:0051234_establishment_of_localization

2189

856

1.16

2.64E-09

0

2.92E-06

GO:0006811_ion_transport

682

297

1.29

2.39E-08

0

1.32E-08

GO:0009966_regulation_of_signal_transduction

408

189

1.37

5.37E-08

0

0.00132

GO:0046578_regulation_of_Ras_protein_signal_transduction

122

70

1.70

6.27E-08

0

0.00014

GO:0007156_homophilic_cell_adhesion

134

75

1.66

8.92E-08

0

6.35E-09

GO:0016337_cell-cell_adhesion

245

121

1.46

2.26E-07

0.000091

1.04E-07

GO:0006468_protein_amino_acid_phosphorylation

536

236

1.31

2.43E-07

0.000083

7.42E-07

GO:0043687_post-translational_protein_modification

1171

473

1.20

2.83E-07

0.000154

0.00097

GO:0007265_Ras_protein_signal_transduction

177

92

1.54

3.59E-07

0.000143

0.00013

GO:0006464_protein_modification_process

1399

555

1.18

3.91E-07

0.0002

0.00721

GO:0007242_intracellular_signaling_cascade

1210

486

1.19

4.26E-07

0.000188

0.00040

GO:0006817_phosphate_transport

83

50

1.79

6.31E-07

0.000176

2.10E-05