Table 1 Densest regions of GWAS associations in the human genome based on analysis of 100 kb bins.
From: An Open Access Database of Genome-wide Association Results
Chr | Position | GWAS assoc. in bin | Density rank | LD adj. rank | Min. p value | Gene(s) | Phenotype(s) in decreasing order of occurrence |
|---|---|---|---|---|---|---|---|
6 | 32405288–32497626 | 177 | 1 | 1 | 5.47E-111 | C6orf10, BTNL2 | RA (65), Type I (50), MS (26), Type II (17), combined WTCCC cases (10), CAD (8), Alzheimer's (1) |
6 | 32703038–32798923 | 107 | 3 | 2 | 1.12E-307 | HLA-DQA1, HLA-DQB1 | Type I (47), RA (30), MS (14), combined WTCCC cases (7), Celiac disease (3), SLE (2), Crohn's disease (1), AAT levels (1), Type II (1), Alzheimer's (1) |
6 | 32806435–32896489 | 116 | 2 | 3 | 4.86E-79 | HLA-DQA1, HLA-DQB1, HLA-DOB | Type I (59), RA (25), MS (21), combined WTCCC cases (9), Early onset obesity (1), 2 hr glucose tolerance test (1) |
2 | 60502647–60591731 | 77 | 5 | 4 | 6.70E-35 | BCL11A | HbF (75), Type II (1), Hypertension (1) |
2 | 60415435–60494833 | 87 | 4 | 5 | 2.50E-12 | downstream from BCL11A | HbF (75), Type II (7), CAD (1), Abdominal aortic calcification (1), combined WTCCC cases (1), Bipolar (1), Parkinson's (1) |
1 | 67406551–67498692 | 65 | 6 | 6 | 3.03E-23 | IL23R | Crohn's disease (60), Psoriasis (2), RA (1), CAD (1), combined WTCCC cases (1) |
9 | 89310993–89384465 | 46 | 9 | 7 | 2.80E-05 | DAPK1 | Alzheimer's (19), HOMA-IR (17), Waist:height (5), Type II (2), Fasting insulin (2), RA (1) |
6 | 151254904–151296407 | 17 | 91 | 8 | 2.90E-08 | MTHFDL1 | CAD (10), Type 1 (2), combined WTCCC cases (1), Hypertension (1), FPG (1), Insulinogenic index (1), ALS (1) |
11 | 5401462–5499595 | 29 | 23 | 9 | 9.46E-24 | HBB, UBQLN3, olfactory receptors | MCV (8), HbA2 (7), RBC (3), HbA1C (1), CAD (3), Type II (3), Fat mass (2), Bipolar disorder (1), Crohn's disease (1) |
16 | 55526649–55589312 | 22 | 43 | 10 | 1.00E-73 | CETP | HDL cholesterol (16), Type II (3), ApoAI (2), HTN (1) |
9 | 116701486–116796674 | 31 | 22 | 11 | 1.61E-09 | TNFSF8, TNC | Crohn's disease (29), 2 hr glucose tolerance test (2) |
8 | 128116770–128194686 | 24 | 31 | 12 | 1.10E-12 | intergenic, 8q24 | Colorectal cancer (10), Prostate cancer (8), Bipolar disorder (3), CAD (2), Hypertension (1) |
8 | 19857092–19899552 | 42 | 11 | 13 | 2.00E-28 | LPL | Triglycerides (22), HDL (11), Triglyceride:HDL (4), CAD (4), RA (1), Hip circumference (1) |
9 | 22102599–22126489 | 26 | 29 | 20 | 1.00E-20 | ANRIL, 3' of CDKN2A/2B | Type II (12), CAD (11), combined WTCCC cases (2), Coronary artery calcification (1) |
10 | 123321680–123395011 | 28 | 24 | 21 | 2.00E-76 | FGFR2 | Breast cancer (24), RA (2), Type II (1), combined WTCCC cases (1) |
6 | 20706282–20796100 | 33 | 21 | 28 | 4.11E-11 | CDKAL1 | Type II (32), Insulin response (1) |
16 | 49300832–49399578 | 47 | 8 | 31 | 2.51E-49 | NOD2 | Crohn's disease (44), RA (1), combined WTCCC cases (1), ApoB (1) |
16 | 52327178–52389272 | 38 | 14 | 33 | 7.30E-14 | FTO | TypeII (15), Hip circumference (15), Early onset obesity (6), Fasting glucose (1), ALS (1) |
10 | 114722872–114798892 | 39 | 13 | 34 | 1.00E-48 | TCF7L2 | Type II (36), Waist:height (2), BMI (1) |
9 | 22007836–22093813 | 52 | 7 | 41 | 2.10E-19 | MTAP, ANRIL, CDKN2A/2B | CAD (48), Coronary artery calcification (2), Type II (2), Type I (1), RA (1) |
17 | 35304874–35382291 | 44 | 10 | 43 | 2.00E-23 | ORMDL3 | Childhood asthma (34), ORMDL3 expression (7), Crohn's disease (3) |
1 | 228303905–228375529 | 24 | 32 | 55 | 7.00E-15 | GALNT2 | Type II (9), Triglycerides (7), HDL (6), Crohn's disease (1), ALS (1) |
16 | 49218265–49298963 | 34 | 19 | 73 | 4.71E-29 | NOD2, SLIC1, CYLD | Crohn's disease (33), Bipolar disorder (1) |
11 | 41805501–41887387 | 34 | 20 | 74 | 5.70E-08 | 11p12, 800 kb from NGL1 | Type II (33), Coronary spasm (1) |
1 | 109608806–109623689 | 23 | 37 | 92 | 1.20E-33 | SORT1, CELSR2, PSRC1, MYBPHL, SARS | LDL cholesterol (16), CAD (4), Total cholesterol (1), Bipolar disorder (1) |
8 | 128404855–128498005 | 23 | 38 | 99 | 1.27E-14 | POU5F1 | Prostate cancer (8), Colorectal cancer (13), Breast cancer (1), Hypertension (1) |
5 | 40513272–40597115 | 40 | 12 | 264 | 8.73E-12 | intergenic, 5p31.1 | Crohn's disease (40) |
20 | 33403387–33489397 | 36 | 17 | 322 | 5.01E-12 | GDF5, UQCC, CEP250 | Height (35), Hypertension (1) |
10 | 64100271–64194296 | 24 | 35 | 494 | 1.00E-10 | ZNF365, ADO, EGR2 | Crohn's disease (16), Type II (8) |
17 | 41401810–41495480 | 38 | 15 | 526 | 3.53E-05 | KIAA1267, MAPT, STH | Crohn's disease (26), Alzheimer's (11), Insulinogenic index (1) |
10 | 44011247–44096316 | 23 | 39 | 647 | 9.46E-08 | intergenic, 10q11.21 | CAD (20), Diastolic blood pressure (2), Fasting glucose (1) |
17 | 41305238–41395352 | 37 | 16 | 746 | 2.78E-05 | KIAA1267, MAPT, STH | Crohn's disease (19), Alzheimer's (18) |
2 | 21223320–21252721 | 27 | 27 | 796 | 8.10E-09 | upstream of APOB | LDL cholesterol (17), Total cholesterol (10) |