Table 2 Association of INSIG2 rs7566605 CC genotype and obesity (BMI ≥ 30) stratified by cohort and race
|  | Obesity OR* | (95% CI) | p*1 | p2 | BMI (± SD) GG/CG | BMI (± SD) CC | p*3 | p4 | Age Obese (± SD) yrs | Age Non- Obese (± SD) yrs | Males Obese (%) | Males Non- Obese (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
ARIC Afr.-Am. | 1.02 | 0.78–1.34 | 0.89 |  | 29.60 (6.15) | 29.94 (5.90) | 0.25 |  | 53.38 (5.75) | 53.58 (5.90) | 26 | 45.9 |
CARDIA Afr.-Am. | 1.01 | 0.64–1.62 | 0.95 |  | 25.41 (5.89) | 25.80 (5.65) | 052 |  | 25.51 (3.72) | 24.20 (3.81) | 25.2 | 44.8 |
GENOA Afr.-Am. | 0.79 | 0.53–1.20 | 0.27 |  | 30.88 (6.62) | 31.28 (6.69) | 0.13 |  | 57.04 (10.23) | 58.26 (10.43) | 19.7 | 42.1 |
ARIC White | 0.95 | 0.82–1.10 | 0.50 |  | 27.03 (4.87) | 26.86 (4.86) | 0.25 |  | 54.42 (5.65) | 54.36 (5.74) | 46.1 | 47.6 |
CARDIA White | 1.07 | 0.64–1.79 | 0.80 |  | 23.73 (4.02) | 23.84 (4.73) | 0.70 |  | 25.94 (3.34) | 25.53 (3.37) | 40.1 | 47.6 |
GENOA White | 0.92 | 0.63–1.32 | 0.64 |  | 30.40 (6.35) | 29.72 (5.27) | 0.24 |  | 54.74 (10.70) | 55.63 (11.13) | 44.5 | 46.6 |
Ottawa Cohort 1 White | 0.79 | 0.50–1.24 | 0.30 |  | NA | NA | - |  | 46.27 (10.23) | 45.57 (12.97) | 37.1 | 36.4 |
Ottawa Cohort 2 White | 1.17 | 0.72–1.92 | 0.53 |  | NA | NA | - |  | 48.37 (10.46) | 45.92 (16.29) | 19.1 | 41.4 |
GENOA Hispanic | 0.94 | 0.64–1.38 | 0.74 |  | 30.90 (6.21) | 29.92 (4.97) | 0.03 |  | 52.77 (11.79) | 56.99 (11.79) | 34.2 | 47.6 |
Combined Studies | 0.96 | 0.86–1.06 |  | 0.38 | 27.85 (5.87) | 27.30 (5.43) |  | 0.15 |  |  |  |  |