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Table 1 INSIG2 allele and genotype frequencies in case and comparison groups stratified by race and cohort

From: The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts

 

n

HW

(p1)

q^

(%)

Obese

(n)

(%)

GC

n

(%)

CG

n

(%)

CC

n

(%)

Non-

Obese

(n)

(%)

GC

n

(%)

CG

n

(%)

CC

n

(%)

(p2)

ARIC

Afr.-Am.

3,870

0.80

24.8

1,570

40.6

910

(57.9)

563

(35.9)

97

(6.2)

2,300

59.4

1,281

(55.7)

875

(38.0)

144

(6.3)

0.36

CARDIA

Afr.-Am.

1,887

0.14

25.6

321

17.0

184

(57.3)

113

(35.2)

24

(7.5)

1,566

83.0

873

(55.7)

581

(37.1)

112

(7.2)

0.81

GENOA

Afr.-Am.

1,731

0.15

25.8

859

49.6

464

(54.0)

350

(40.8)

45

(5.2)

872

50.4

477

(54.7)

356

(38.5)

59

(6.8)

0.32

ARIC

White

10,696

0.61

33.2

2,430

22.7

1,099

(45.2)

1,070

(44.0)

261

(10.8)

8,266

77.3

3,689

(44.6)

3,649

(44.2)

928

(11.2)

0.76

CARDIA

White

2,001

0.34

33.8

142

4.4

59

(41.5)

65

(45.8)

18

(12.7)

1,859

95.6

828

(44.6)

811

(43.6)

220

(11.8)

0.78

GENOA

White

1,421

0.06

31.6

647

45.5

302

(46.7)

290

(44.8)

55

(8.5)

774

54.5

348

(44.9)

355

(45.9)

71

(9.2)

0.78

Ottawa

Cohort 1

White

754

0.57

33.5

380

50.4

176

(46.3)

164

(43.2)

40

(10.5)

374

49.6

161

(43.1)

165

(44.1)

48

(12.8)

0.51

Ottawa

Cohort 2

White

748

0.82

32.2

371

49.6

175

(47.2)

155

(41.8)

41

(11.0)

377

50.4

168

(44.6)

174

(46.1)

35

(9.3)

0.44

GENOA

Hispanic

1,614

0.43

26.6

793

49.1

421

(53.1)

313

(39.5)

59

(7.4)

821

50.9

456

(55.5)

304

(37.0)

61

(7.5)

0.58

  1. Afr.-Am., African-American; n, number; HW, Hardy-Weinberg equilibrium; q^, frequency of the INSIG2 rs7566605 C allele; p1, p-value for chi-squared goodness-of-fit test for Hardy-Weinberg equilibrium; p2, p-value Pearson chi-squared