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Table 4 Estimates of Heritability ± SE for LV Structure and Function Phenotypes in African American and White Families

From: Identification of a pleiotropic locus on chromosome 7q for a composite left ventricular wall thickness factor and body mass index: the HyperGEN Study

Phenotype African American White
  Min Adj* Max Adj** Min Adj* Max Adj**
Interventricular septal thickness 0.33 ± 0.07 0.29 ± 0.07 0.42 ± 0.07 0.42 ± 0.07
LV internal diameter 0.51 ± 0.07 0.46 ± 0.07 0.41 ± 0.07 0.37 ± 0.07
Posterior wall thickness 0.33 ± 0.07 0.29 ± 0.07 0.41 ± 0.07 0.40 ± 0.07
Relative wall thickness 0.25 ± 0.07 0.23 ± 0.07 0.54 ± 0.07 0.56 ± 0.07
LV Mass 0.57 ± 0.07 0.58 ± 0.07 0.46 ± 0.07 0.35 ± 0.07
LV transmitral atrial phase peak filling velocity† 0.40 ± 0.07 0.43 ± 0.07 0.40 ± 0.07 0.33 ± 0.07
LV transmitral early peak filling velocity† 0.44 ± 0.07 0.44 ± 0.07 0.43 ± 0.07 0.43 ± 0.07
Stress-corrected midwall shortening 0.26 ± 0.07 0.26 ± 0.07 0.13 ± 0.07 0.11 ± 0.06
LV wall thickness factor 0.36 ± 0.07 0.33 ± 0.07 0.44 ± 0.07 0.44 ± 0.07
LV diastolic filling factor† 0.49 ± 0.07 0.49 ± 0.07 0.45 ± 0.07 0.44 ± 0.07
  1. Estimates of heritability for all traits are significant at p < 0.05;
  2. *Adjusted for age, age2, and gender;
  3. **Additionally adjusted for BMI, SBP, diabetes, current smoking, and heart rate (for variables labeled with † only).