Identification of a pleiotropic locus on chromosome 7q for a composite left ventricular wall thickness factor and body mass index: the HyperGEN Study

Table 4 Estimates of Heritability ± SE for LV Structure and Function Phenotypes in African American and White Families

Phenotype	African American		White
	Min Adj*	Max Adj**	Min Adj*	Max Adj**
Interventricular septal thickness	0.33 ± 0.07	0.29 ± 0.07	0.42 ± 0.07	0.42 ± 0.07
LV internal diameter	0.51 ± 0.07	0.46 ± 0.07	0.41 ± 0.07	0.37 ± 0.07
Posterior wall thickness	0.33 ± 0.07	0.29 ± 0.07	0.41 ± 0.07	0.40 ± 0.07
Relative wall thickness	0.25 ± 0.07	0.23 ± 0.07	0.54 ± 0.07	0.56 ± 0.07
LV Mass	0.57 ± 0.07	0.58 ± 0.07	0.46 ± 0.07	0.35 ± 0.07
LV transmitral atrial phase peak filling velocity†	0.40 ± 0.07	0.43 ± 0.07	0.40 ± 0.07	0.33 ± 0.07
LV transmitral early peak filling velocity†	0.44 ± 0.07	0.44 ± 0.07	0.43 ± 0.07	0.43 ± 0.07
Stress-corrected midwall shortening	0.26 ± 0.07	0.26 ± 0.07	0.13 ± 0.07	0.11 ± 0.06
LV wall thickness factor	0.36 ± 0.07	0.33 ± 0.07	0.44 ± 0.07	0.44 ± 0.07
LV diastolic filling factor†	0.49 ± 0.07	0.49 ± 0.07	0.45 ± 0.07	0.44 ± 0.07

Estimates of heritability for all traits are significant at p < 0.05;
*Adjusted for age, age², and gender;
**Additionally adjusted for BMI, SBP, diabetes, current smoking, and heart rate (for variables labeled with † only).

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