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Table 1 The location, minor allele frequency, and crude association analyses of 25 SNPs spanning both TRPM6 and TRPM7 loci

From: Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women

   

Minor allele frequency (MAF)

P values for crude associationb

SNP

Alleles

(major/minor)

Locationa

Cases

Controls

Genotypic recessive

Genotypic additive

Genotypic dominant

rs4745363 (46)

T>A

Intron 1

0.46

0.42

0.08

0.18

0.59

rs10869447 (45)

A>G

Intron 3

0.39

0.35

0.05

0.25

0.79

rs11144108 (44)

T>G

Intron 6

0.36

0.35

0.20

0.67

0.77

rs7867868 (43)

C>T

Intron 6

0.33

0.32

0.56

0.75

0.41

rs7045949 c(42)

C>T (in only European whites)

Intron 7

0.41

0.42

0.91

0.76

0.59

rs1012710 (41)

T>C

Intron 12

0.30

0.30

0.93

0.97

0.91

rs10512038 (40)

T>C

Intron 14

0.25

0.28

0.83

0.28

0.21

rs7859201d(39)

A>C

(Leu708Leu)

Exon 17

0.39

0.43

0.32

0.11

0.13

rs3858116 (38)

G>A

Intron 18

0.38

0.40

0.78

0.46

0.39

rs2151424 (37)

C>T

Intron 19

0.26

0.28

0.13

0.37

0.74

rs2151423 (36)

A>G

(whites only)

Intron 19

0.45

0.46

0.43

0.91

0.60

rs6560408 (35)

C>T

Intron 23

0.39

0.40

0.90

0.74

0.56

rs3750425e(34)

G>A (Val1393Ile)

Exon 26

0.097

0.095

0.29

0.86

0.89

rs2274924f(33)

A>G

(Lys1584Glu)

Exon 27

0.18

0.18

0.42

0.79

0.51

rs2769195 (32)

T>C

Intron 27

0.44

0.42

0.03

0.33

0.69

rs1327824 (31)

G>C

Intron 31

0.09

0.11

0.50

0.46

0.53

rs875034 (30)

A>G

Intron 33

0.42

0.42

0.91

0.84

0.83

rs944857 (29)g

T>C

Intron 36

0.02

0.009

--

0.07

0.07

rs539079 (28)

A>G

Intron 36

0.10

0.09

0.67

0.91

0.99

rs514348 (27)

T>A

Intron 38

0.41

0.40

0.09

0.80

0.35

TRPM7

       

rs8042919h(51)

G>A (Thr1482Ile)

Exon 28

0.10

0.12

0.27

0.19

0.27

rs3109881(50)

G>A

3'UTR

0.36

0.41

0.15

0.04

0.07

rs10519279 (49)

G>C

3'UTR

0.16

0.19

0.40

0.19

0.22

rs3131597 (48)

C>T

3'UTR

0.41

0.46

0.10

0.13

0.36

rs3098198 (47)

A>G

3'UTR

0.47

0.41

0.13

0.03

0.03

  1. a: The location was based on the contiguous position (reference NT_023935.17 for TRPM6 and NT_010194.16 for TRPM7);
  2. b: Adjusted for two matching variables (age and race).
  3. c: Exon-intron boundary region;
  4. d: Synonymous polymorphism (Leu708Leu)
  5. e: Non-synonymous polymorphism in TRPM6: Protein residue: Val1393 Ile
  6. f: Non-synonymous polymorphism in TRPM6: Protein residue: Lys1584Glu
  7. g: No homozygosity observed for rare allele A;
  8. h: Non-synonymous polymorphism in TRPM7: Protein residue: Ile482Thr