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Table 3 Summary of linkage analyses

From: Genome screen in familial intracranial aneurysm

Chromosome1/Position2

Model Independent Linkage Analysis

LOD score

Ordered Subset Analysis

Gene × smoking LOD score (p-value3)

Parametric Linkage Analysis

LOD score

 

Narrower4

Broader5

Narrower4

Broader5

Narrower4

Broader5

4q32.3/160–162 cM

0.5

1.3

NS6

NS

1.6

2.6

7p14.1/60–63 cM

0.7

0.6

4.1 (0.001)

3.2 (0.01)

0.4

0.7

7q22.3/116–118 cM

1.5

1.3

NS

NS

1.6

1.3

12p12.3/35–50 cM

1.4

1.4

NS

NS

2.4

3.1

  1. 1 Cytogenetic position of the maximum LOD score
  2. 2 Location of the maximum LOD score on the deCode map
  3. 3 Permutation testing was performed to obtain p-values associated with the increase in LOD score observed when modeling gene × smoking interaction when compared with modeling for genetic effects only.
  4. 4 Narrower disease model (n = 290 families)
  5. 5 Broader disease model (n = 333 families)
  6. 6 Not significant