From: Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease
Reference SNP | Homozygou wild-type | Presence of minor allele | p-value | 95% confidence interval for coefficient | ||
---|---|---|---|---|---|---|
 | n (%) | n (%) | n (%) | n (%) |  |  |
 | Case-control | |||||
 | Cases | Controls | Cases | Controls |  |  |
rs8078340 | 172 (59) | 485 (54) | 122 (41) | 412 (46) | 0.078 | -0.59, 0.03 |
rs2779248 | 260 (88) | 797 (87) | 37 (12) | 121 (13) | 0.431 | -0.65, 0.28 |
rs16966563 | 203 (69) | 634 (70) | 90 (31) | 270 (30) | 0.714 | -0.27, 0.39 |
rs3794763 | 193 (65) | 575 (63) | 102 (35) | 337 (37) | 0.331 | -0.16, 0.48 |
rs1137933 | 183 (63) | 580 (64) | 109 (37) | 326 (36) | 0.908 | -0.30, 0.34 |
rs17718148 | 212 (72) | 677 (75) | 81 (28) | 229 (25) | 0.718 | -0.28, 0.40 |
rs4796052 | 201 (67) | 673 (73) | 97 (33) | 240 (27) | 0.106 | -0.06, 0.59 |
rs2314809 | 158 (55) | 485 (54) | 131 (45) | 415 (46) | 0.956 | -0.32, 0.30 |
rs2297512 | 157 (53) | 496 (55) | 138 (47) | 407 (45) | 0.913 | -0.29, 0.32 |
 | Survival (all IPD cases) | |||||
 | Non-survivors | Survivors | Non-survivors | Survivors |  |  |
rs8078340 | 33 (51) | 139 (61) | 32 (49) | 90 (39) | 0.675 | -1.09, 0.70 |
rs2779248 | 57 (88) | 203 (88) | 8 (12) | 29 (12) | 0.936 | -1.14, 1.24 |
rs16966563 | 41 (63) | 162 (71) | 24 (37) | 66 (29) | 0.935 | -0.90, 0.98 |
rs3794763 | 39 (60) | 154 (67) | 26 (40) | 76 (33) | 0.101 | -0.16, 1.75 |
rs1137933 | 36 (56) | 147 (64) | 28 (44) | 81 (36) | 0.592 | -0.68, 1.19 |
rs17718148 | 40 (62) | 172 (74) | 25 (38) | 59 (26) | 0.811 | -1.11, 0.86 |
rs4796052 | 40 (62) | 161 (69) | 25 (38) | 72 (31) | 0.194 | -1.54, 0.31 |
rs2314809 | 37 (58) | 121 (54) | 27 (42) | 104 (46) | 0.684 | -0.72, 1.10 |
rs2297512 | 37 (57) | 121 (52) | 28 (43) | 110 (48) | 0.558 | -0.64, 1.19 |
 | Survival (meningitis cases only) | |||||
 | Non-survivors | Survivors | Non-survivors | Survivors |  |  |
rs8078340 | 27 (47) | 100 (62) | 30 (53) | 61 (38) | 0.567 | -1.20, 0.66 |
rs2779248 | 49 (86) | 138 (85) | 8 (14) | 24 (15) | 0.783 | -1.37, 1.03 |
rs16966563 | 35 (61) | 112 (70) | 22 (39) | 47 (30) | 0.608 | -0.93, 0.55 |
rs3794763 | 35 (61) | 105 (65) | 22 (39) | 56 (35) | 0.117 | -0.20, 1.77 |
rs1137933 | 35 (63) | 99 (62) | 21 (37) | 60 (38) | 0.623 | -0.72, 1.21 |
rs17718148 | 38 (67) | 118 (73) | 19 (33) | 44 (27) | 0.634 | -1.25, 0.76 |
rs4796052 | 37 (65) | 114 (70) | 20 (35) | 49 (30) | 0.153 | -1.66, 0.26 |
rs2314809 | 31 (55) | 86 (54) | 25 (45) | 73 (46) | 0.666 | -0.75, 1.17 |
rs2297512 | 32 (56) | 89 (55) | 25 (44) | 73 (45) | 0.521 | -0.64, 1.26 |