|
Phenotype*
|
---|
Gene
| BODE index | MRC score | 6MWD, meters | Maximum workload, Watts | BMI, Kg/m2 | FEV1, L |
---|
IL6
| 0.38 | 0.41 | 0.48 | 0.81 | 0.66 | 0.22 |
CRP
| 0.33 | 0.41 | 0.11 | 0.06 | 0.56 | 0.70 |
FGB
| 0.74 | 0.61 | 0.61 | 0.64 | 0.44 | 0.72 |
- *Global association tests were adjusted for marker-specific clinical covariates selected by backward linear regression. Age and sex were included in all final models.
- Other covariates included in regression models per phenotype:
- BODE index: smoking status (former/current), PCO2 (kPa)
- MRC score: FEV1 (liters), smoking status (former/current)
- 6MWD: FEV1 (liters), Charlson co morbidity index, diastolic blood pressure, smoking status (former/current).
- Maximum workload: FEV1 (liters), Charlson co morbidity index, diastolic blood pressure, PCO2 (kPa), height.
- BMI: FEV1 (liters), smoking status (former/current), diastolic blood pressure, PCO2 (kPa)
- FEV1: Height, systolic and diastolic blood pressure, PCO2 (kPa) and PO2 (kPa).