IL6 and CRPhaplotypes are associated with COPD risk and systemic inflammation: a case-control study

BMC Medical Genetics

Table 3 Tagging SNPs characteristics and single SNP association analysis for COPD

dbSNP No.	tagSNP*	Gene region	Minor allele frequency		P-value alleles†	OR adj‡ genotypes (95%CI)	P-value genotypes
			Controls	COPD
*IL6 gene* (7p21-p15)
rs2069825	205CT/-	5'flanking	0.42	0.37	0.11	0.87 (0.64–1.17)	0.35
rs2069827	321G/T	5'flanking	0.10	0.07	0.10	0.67 (0.39–1.14)	0.14
rs1800797	1086G/A	5'flanking	0.44	0.39	0.12	0.86 (0.64–1.16)	0.32
rs2069840	3437C/G	intron	0.34	0.36	0.52	1.04 (0.76–1.42)	0.81
rs1554606	3572G/T	intron	0.46	0.42	0.19	0.84 (0.62–1.13)	0.25
rs2069849	6021C/T	synonymous	0.03	0.02	0.33	0.51 (0.19–1.36)	0.18
rs2069861	6519C/T	3'flanking	0.11	0.09	0.24	0.93 (0.57–1.52)	0.77
rs1818879	7592G/A	3'flanking	0.32	0.39	0.02	1.49 (1.08–2.04)	0.01
*CRP gene* (1q21-q23)
rs3091244	1440C/T	5'flanking	0.30	0.31	0.08	1.01 (0.73–1.40)	0.94
	1440C/A		0.06	0.08		1.57 (0.88–2.79)	0.12
rs1800947	2667G/C	synonymous	0.05	0.08	0.03	1.80 (0.96–3.37)	0.06
rs1130864	3014C/T	3' UTR	0.30	0.31	0.65	1.05 (0.76–1.46)	0.76
rs1205	3872G/A	3'-flanking	0.35	0.33	0.41	0.98 (0.73–1.32)	0.91
rs2808630	5237A/G	3'-flanking	0.29	0.27	0.55	0.83 (0.60–1.15)	0.27
rs3090077	6469A/C	3'-flanking	0.05	0.08	0.15	1.59 (0.86–2.96)	0.14
*FGB gene* (4q28)
rs1800791	1038G/A	5' flanking	0.18	0.17	0.63	0.80 (0.55–1.18)	0.26
rs1800788	1643C/T	5' flanking	0.18	0.21	0.31	1.36 (0.94–1.95)	0.10
rs1800787	1744C/T	5' flanking	0.21	0.20	0.59	1.10 (0.75–1.61)	0.62
rs2227421	9952A/C	3' UTR	0.31	0.33	0.59	1.03 (0.74–1.42)	0.87

* TagSNPs are numbered by position in sequences AF449713 for CRP, AF372214 for IL6 and AF388026 for FGB. Base change common allele/rare allele.
† P value is for the test of allele counting in cases versus controls.
‡ Logistic regression analysis was adjusted for age, sex and tobacco consumption (pack-years smoked)

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