From: Contrasting genetic association of IL2RAwith SLE and ANCA – associated vasculitis
SLE | AAV | |||
---|---|---|---|---|
KRUK cases | Imperial cases | Imperial trios | ||
rs11594656 T>A | ||||
Genotyped cases | 208 | 441 | 481 | 670 |
TT, TA, AA | 148, 52, 8 | 276, 145, 20 | 382, 252, 36 | |
Genotyped controls | 4401 | 4449 | 310 * | 8850 |
TT, TA, AA | 2486, 1655, 260 | 2542, 1640, 267 | 5028, 3295, 527 | |
MAF in cases | 0.16 | 0.20 | - | 0.24 |
P value (1 d.f. test) | 1 × 10-4 | 0.0221 | 2.8 × 10-3 | 0.7481 |
OR for minor allele | 0.595 | 0.82 | - | 1.02 |
95% CI for OR | 0.4570 – 0.7756 | 0.6931 – 0.9723 | - | 0.8972 – 1.163 |
rs41295061 C>A | ||||
Genotyped cases | 208 | 421 | 471 | 675 |
CC, CA, AA | 172, 33, 3 | 330, 80, 11 | 569, 102, 4 | |
Genotyped controls | 4438 | 4498 | 137 * | 8936 |
CC, CA, AA | 3603, 790, 45 | 3603, 832, 63 | 7206, 1622, 108 | |
MAF in cases | 0.09 | 0.12 | - | 0.08 |
P value (1 d.f. test) | 0.7187 | 0.1899 | 0.2000 | 0.0122 |
OR for minor allele | 0.94 | 1.154 | - | 0.7739 |
95% CI for OR | 0.6710 – 1.317 | 0.9307 – 1.438 | - | 0.6330 – 0.9461 |
rs2104286 A>G | ||||
Genotyped cases | 198 | 436 | 471 | 380 |
AA, AG, GG | 113, 74, 11 | 234, 158, 44 | 207, 148, 25 | |
Genotyped controls | 3475 | 3529 | 353 * | 7004 |
AA, AG, GG | 1823, 1403, 249 | 1825, 1452, 252 | 3648, 2855, 501 | |
MAF in cases | 0.24 | 0.28 | - | 0.26 |
P value (1 d.f. test) | 0.1760 | 0.7568 | 0.558 | 0.3727 |
OR for minor allele | 1.177 | 0.9756 | - | 1.078 |
95% CI for OR | 0.9294 – 1.490 | 0.8343 – 1.141 | - | 0.9133 – 1.273 |