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Table 2 Results for (A) weight-for-height z-score and (B) reproductive success§ for 16 SNPs in FTO gene

From: FTOgene variation and measures of body mass in an African population

   

(A) weight-for-height zscore1

(B) Reproductive success§2

SNP

base change

MAF [%]

coef

CI95%

p

% diff in birth rate

CI95%

p

rs6499642

C/T

32.07

0.0373

(-0.0307, 0.1052)

0.2725

4.7%

(-1.0%, 10.9%)

0.1017

rs6499643

C/T

43.07

0.0561

(-0.0073, 0.1194)

0.0767

0.1%

(-5.0%, 5.5%)

0.9665

rs7206790

C/G

39.68

-0.0313

(-0.0950, 0.0324)

0.3262

-4.0%

(-9.0%, 1.4%)

0.1354

rs9940646

C/G

41.26

0.0145

(-0.0497, 0.0788)

0.6511

-0.7%

(-5.6%, 4.5%)

0.7842

rs12447107

C/G

31.31

0.0152

(-0.0526, 0.0831)

0.6534

-1.9%

(-7.0%, 3.5%)

0.4801

rs17817288

A/G

37.91

-0.0016

(-0.0678, 0.0646)

0.9612

4.3%

(-0.7%, 9.5%)

0.0845

rs16945088

A/G

40.91

0.0281

(-0.0365, 0.0927)

0.3846

5.1%

(0.2%, 10.1%)

0.0356

rs17817449

G/T

34.50

-0.0039

(-0.0700, 0.0621)

0.9052

-0.9%

(-5.6%, 4.0%)

0.7046

rs8063946

C/T

41.93

0.0127

(-0.0518, 0.0772)

0.6932

3.0%

(-1.7%, 7.9%)

0.2068

rs3751812

G/T

4.39

0.0164

(-0.1376, 0.1703)

0.8317

7.2%

(-2.7%, 18.1%)

0.1535

rs3751813

G/T

44.43

-0.0243

(-0.0883, 0.0397)

0.4471

4.2%

(-0.8%, 9.4%)

0.0929

rs9939609

A/T

35.54

0.0019

(-0.0614, 0.0653)

0.9512

-3.3%

(-7.7%, 1.3%)

0.1510

rs9931494

C/G

12.42

0.0479

(-0.0467, 0.1425)

0.3117

-1.5%

(-7.7%, 5.2%)

0.6475

rs7190492

A/G

23.07

-0.0397

(-0.1136, 0.0342)

0.2828

-1.9%

(-7.7%, 4.4%)

0.5421

rs7204609

C/T

46.76

-0.0168

(-0.0819, 0.0482)

0.6044

-3.1%

(-7.6%, 1.6%)

0.1787

rs9935403

G/A

15.00

0.0644

(-0.0194, 0.1482)

0.1244

-0.8%

(-7.2%, 6.0%)

0.8003

  1. Key: SNP single nucleotide polymorphism; MAF minor allele frequency
  2. §as number of babies born (interpreted taking account of the mother's age and duration of observation)
  3. 1 Sample size ranged between 2127 and 2164 and the number of family groups between 954 and 966 depending on SNP. Family group sizes ranged between 1 and 8.
  4. 2 Sample size ranged between 657 and 672 and number of family groups between 484 and 495 depending on SNP. Family group sizes ranged between 1 and 5. Total exposure ranged between 420 and 428 "reproductive lifetimes" and the number of births between 2985 and 3062.
  5. The tabulated p-values are not corrected for multiple testing. The Bonferroni correction to account for testing 16 SNPs and achieve significance at the 5% level requires that the uncorrected p-value should be < 0.0033. In no case is this cut-off reached.
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BMC Medical Genetics

ISSN: 1471-2350

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