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Table 2 Results of hierarchical logistic regression analysis aimed at determining whether the TP53 codon 72 and DRD4 uVNTR polymorphisms were associated with schizophrenia after the contributions of age and gender were taken into account.

From: Association of DRD4 uVNTR and TP53 codon 72 polymorphisms with schizophrenia: a case-control study

Model 1.       
Variables B S.E. Wald df Sig. Exp(B)
Gender --0.891 0.128 48.735 1 < 0.001** 0.410
Age --0.045 0.005 83.772 1 < 0.001** 0.956
P53CC 0.218 0.171 1.618 1 0.203 1.244
P53GG 0.083 0.146 0.320 1 0.571 1.086
Constant 3.760 0.276 185.052 1 < 0.001 42.954
Model 2.       
Variables B S.E. Wald df Sig. Exp(B)
Gender --0.891 0.128 48.735 1 < 0.001** 0.410
Age --0.045 0.005 83.772 1 < 0.001** 0.956
DRD4c 0.841 0.401 4.393 1 0.036* 2.319
Constant 3.777 0.270 195.381 1 < 0.001 43.668
Model 3.       
Variables B S.E. Wald df Sig. Exp(B)
Gender --0.891 0.128 48.735 1 < 0.001** 0.410
Age --0.045 0.005 83.772 1 < 0.001** 0.956
DRD4c by p53CC 1.459 1.054 1.916 1 0.166 4.302
Constant 3.819 0.270 200.781 1 < 0.001 45.573
  1. B: coefficient of regression; S.E.: Standard Error; Wald: the index of regression effect; df: degrees of freedom; Sig: P value; Exp(B): odds ratio; p53CC: dummy variable where 1 refers to the CC genotype of the TP53 codon 72 polymorphism and 0 refers to the other possible genotypes; p53GG: dummy variable where 1 refers to the GG genotype of the TP53 codon 72 polymorphism and 0 refers to the other possible genotypes; DRD4c: dummy variable where 1 refers to the long form allelic variants of the DRD4 uVNTR polymorphism (≥ 5 repeats) and 0 refers to the short form allelic variants (≤ 4 repeats); DRD4c by p53CC: the genetic effect attributed to the possible interaction between the long form variants of the DRD4 uVNTR polymorphism and the CC genotype of the TP53 codon 72 polymorphism; ** indicates statistical significance (p < 0.001).