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Table 1 The distributions of genotypes and alleles for the TP53 codon 72 and DRD4 uVNTR polymorphisms.

From: Association of DRD4 uVNTR and TP53 codon 72 polymorphisms with schizophrenia: a case-control study

Polymorphism Genotype frequency (%) HWE-p p value Allele frequency (%) P value Odds ratio (95% CI)
rs8064946 C/C C/G G/G    C (Pro72) G (Arg72)   
Patient (n = 917) 193 (21.05) 453 (49.40) 271(29.55) 0.884 0.229 839 (45.75) 995 (54.25) 0.404 1.072 (0.910--1.262)a
Control (n = 427) 74 (17.33) 228 (53.40) 125 (29.27) 0.084   376 (44.03) 478 (55.97)   
DRD4 uVNTR 2/2 2/3 2/4 2/5 3/3 3/4 3/5 4/4 4/5 4/6 5/6    Short (≤ 4 repeats) Long (≥ 5 repeats)   
Patient (n = 914) 60 0 263 8 1 16 1 521 24 19 1   < 0.001 1774 (97.05) 54 (2.95) 0.001 3.189 1.535--6.622)b
Control (n = 423) 49 1 78 3 1 6 0 280 2 3 0    838 (99.05) 8 (0.95)   
  1. Genotyping results for the TP53 codon 72 polymorphism were lacking for 17 patients with schizophrenia and six controls; genotyping information for the DRD4 uVNTR polymorphism was lacking for 20 patients with schizophrenia and 10 controls; HWE-p: p value of chi-square test for Hardy--Weinberg Equilibrium; a: odds ratio of the C allele to the G allele of the codon 72 polymorphism in TP53in relation to schizophrenia; b: odds ratio of the long form variants (≥ 5 repeats) to the short form variants (≤ 4 repeats) shows the former confers enhanced risk of vulnerability to schizophrenia.