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Table 7 Proportions of cases and controls with different SNP-genotypes at the CSF2 locus and risk estimates from conditional logistic regression (CLR) analysis of 651 matched case-control pairs for each SNP for scarring trachoma.

From: Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians

   

Multiplicative model

Dominant model

Recessive model

Genotype

# of genotypes (freq)

CLR

OR (95%CI)

OR (95%CI)

 

TS cases

controls

OR (95%CI)

P value

P value

P value

GM-CSF2_27348 TT

391(0.65)

384(0.61)

Reference

-

0.86(0.67,1.09)

0.60(0.33,0.084)

GM-CSF2_27348 TA

193(0.32)

207(0.33)

0.90(0.70,1.57)

0.414

0.200

0.084

GM-CSF2_27348 AA

22 (0.04)

36 (0.06)

0.58(0.32,1.04)

0.069

  

Test for trend

  

0.84(0.69,1.03)

0.091

  

GM-CSF2_2069614 CC

206(0.32)

198(0.31)

Reference

-

0.88(0.68,1.28)

0.99 (0.74,1.31)

GM-CSF2_2069614 CT

306(0.48)

316(0.49)

0.87(0.67,1.31)

0.300

0.310

0.922

GM-CSF2_2069614 TT

124(0.19)

130(0.20)

0.90(0.65,1.26)

0.546

  

Test for trend

  

0.94(0.80,1.11)

0.467

  

GM-CSF2_27438 AA

215(0.33)

233(0.36)

Reference

-

1.08(0.85,1.37)

1.37 (1.02,1.85)

GM-CSF2_27438 AG

301(0.47)

318(0.49)

1.00(0.78,1.29)

0.991

0.542

0.037

GM-CSF2_27438 GG

126(0.20)

100(0.15)

1.37(0.98,1.93)

0.066

  

Test for trend

  

1.14(0.97,1.35)

0.113

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