Skip to main content

Advertisement

Table 3 risk effects estimated by OR (95%CI) for the association between extended (H1, L1) and reduced (H2, L2) haplotypes with scarring trachoma and trichiasis.

From: Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians

HAPa SNP b CLR test for trend
           Scarring trachoma Trichiasis
  1 2 3 4 5 6 7 8 9 OR 95%CI p value OR 95%CI p value
H1 G A A T A T T A C 1.671 1.19,2.35 0.003 1.616 1.08, 2.42 0.020
H2 - A A - A - - - - 1.541 1.14,2.08 0.005 1.510 1.05, 2.15 0.025
L1 A G G T A T T A C 0.556 0.36,0.87 0.010 0.685 0.40, 1.16 0.161
L2 - G G - A - - - - 0.490 0.27,0.89 0.021 0.725 0.378,1.39 0.334
  1. a Significant associations are fine-mapped to four contiguous ht SNPs bounded by AFM+1666 and IL8-251 (H2 and L2 haplotypes). Regression modelling with PHASE inferred haplotypes from progressively reducing SNP sets showed increased risk effects of similar magnitude in the reduced set compared to those detected by the full length haplotypes.
  2. b Refer to table 1 for SNP information