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Table 1 Distribution of DYRK1A polymorphisms in patients and controls stratified by APOE ε4 allele

From: DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort

DYRK1A polymorphism

APOE ε4 allele noncarriers

APOE ε4 allele carriers

Total sample

 

Patients

Controls

Patients

Controls

Patients

Controls

rs11701483

AA

226 (0.78)

486 (0.79)

273 (0.83)

85 (0.74)

499 (0.81)

571 (0.79)

 

AG

58 (0.20)

119 (0.20)

54 (0.16)

27 (0.24)

112 (0.18)

146 (0.20)

 

GG

6 (0.02)

7 (0.01)

3 (0.01)

2 (0.02)

9 (0.01)

9 (0.01)

 

Total

290

612

330

114

620

726

 

Allele frequency A/G

0.88/0.12

0.89/0.11

0.91/0.09

0.86/0.14

0.89/0.11

0.89/0.11

rs2835740

TT

187 (0.65)

366 (0.62)

217 (0.66)

74 (0.66)

404 (0.66)

440 (0.62)

 

TC

86 (0.30)

206 (0.35)

90 (0.28)

31 (0.28)

176 (0.29)

237 (0.34)

 

CC

13 (0.05)

24 (0.04)

19 (0.06)

7 (0.06)

32 (0.05)

31 (0.04)

 

Total

286

596

326

112

612

708

 

Allele frequency T/C

0.80/0.20

0.79/0.21

0.80/0.20

0.80/0.20

0.80/0.20

0.79/0.21

rs1137600

AA

124 (0.44)

276 (0.46)

164 (0.53)

50 (0.45)

288 (0.49)

326 (0.46)

 

AG

124 (0.44)

261 (0.43)

107 (0.35)

46 (0.42)

231 (0.39)

307 (0.43)

 

GG

32 (0.12)

69 (0.11)

37 (0.12)

14 (0.13)

69 (0.12)

83 (0.12)

 

Total

280

606

308

110

588

716

 

Allele frequency A/G

0.62/0.38

0.67/0.33

0.71/0.29

0.66/0.34

0.69/0.31

0.67/0.33

rs2835761

CC

203 (0.70)

422 (0.69)

232 (0.72)

84 (0.75)

435 (0.71)

506 (0.70)

 

CT

82 (0.29)

176 (0.29)

85 (0.26)

27 (0.24)

167 (0.27)

203 (0.28)

 

TT

4 (0.01)

11 (0.02)

6 (0.02)

1 (0.01)

10 (0.02)

12 (0.02)

 

Total

289

609

323

112

612

721

 

Allele frequency C/T

0.84/0.16

0.84/0.16

0.85/0.15

0.87/0.13

0.85/0.15

0.84/0.16

rs2835762

CC

216 (0.81)

467 (0.78)

243 (0.77)

82 (0.73)

459 (0.79)

549 (0.78)

 

CT

49 (0.18)

119 (0.20)

69 (0.22)

27 (0.24)

118 (0.20)

146 (0.21)

 

TT

3 (0.01)

9 (0.02)

4 (0.01)

3 (0.03)

7(0.01)

12 (0.01)

 

Total

268

595

316

112

584

707

 

Allele frequency C/T

0.90/0.10

0.88/0.12

0.88/0.12

0.85/0.15

0.89/0.11

0.88/0.12

rs2154545

GG

105 (0.37)

218 (0.36)

141 (0.43)

43 (0.38)

246 (0.40)

261 (0.36)

 

GA

136 (0.47)

280 (0.46)

135 (0.42)

49 (0.44)

271 (0.44)

329 (0.46)

 

AA

45 (0.16)

108 (0.18)

50 (0.15)

20 (0.18)

95 (0.16)

128 (0.18)

 

Total

286

606

326

112

612

718

 

Allele frequency G/A

0.60/0.40

0.59/0.41

0.64/0.36

0.60/0.40

0.62/0.38

0.59/0.41

rs8132976

AA

95 (0.34)

194 (0.33)

93 (0.29)

33 (0.30)

188 (0.31)

227 (0.32)

 

AC

122 (0.43)

285 (0.48)

138 (0.43)

48 (0.43)

260 (0.43)

333 (0.47)

 

CC

66 (0.23)

116 (0.19)

91 (0.28)

30 (0.27)

157 (0.26)

146 (0.21)

 

Total

283

595

322

111

605

706

 

Allele frequency A/C

0.55/0.45

0.57/0.43

0.50/0.50

0.51/0.49

0.53/0.47

0.56/0.44

  1. Figures in parentheses indicate frequencies; p-values > 0.05 for all allelic and genotypic comparisons; p-values were not corrected for multiple comparisons.