From: DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort
DYRK1A polymorphism | APOE ε4 allele noncarriers | APOE ε4 allele carriers | Total sample | ||||
---|---|---|---|---|---|---|---|
Patients | Controls | Patients | Controls | Patients | Controls | ||
rs11701483 | AA | 226 (0.78) | 486 (0.79) | 273 (0.83) | 85 (0.74) | 499 (0.81) | 571 (0.79) |
AG | 58 (0.20) | 119 (0.20) | 54 (0.16) | 27 (0.24) | 112 (0.18) | 146 (0.20) | |
GG | 6 (0.02) | 7 (0.01) | 3 (0.01) | 2 (0.02) | 9 (0.01) | 9 (0.01) | |
Total | 290 | 612 | 330 | 114 | 620 | 726 | |
Allele frequency A/G | 0.88/0.12 | 0.89/0.11 | 0.91/0.09 | 0.86/0.14 | 0.89/0.11 | 0.89/0.11 | |
rs2835740 | TT | 187 (0.65) | 366 (0.62) | 217 (0.66) | 74 (0.66) | 404 (0.66) | 440 (0.62) |
TC | 86 (0.30) | 206 (0.35) | 90 (0.28) | 31 (0.28) | 176 (0.29) | 237 (0.34) | |
CC | 13 (0.05) | 24 (0.04) | 19 (0.06) | 7 (0.06) | 32 (0.05) | 31 (0.04) | |
Total | 286 | 596 | 326 | 112 | 612 | 708 | |
Allele frequency T/C | 0.80/0.20 | 0.79/0.21 | 0.80/0.20 | 0.80/0.20 | 0.80/0.20 | 0.79/0.21 | |
rs1137600 | AA | 124 (0.44) | 276 (0.46) | 164 (0.53) | 50 (0.45) | 288 (0.49) | 326 (0.46) |
AG | 124 (0.44) | 261 (0.43) | 107 (0.35) | 46 (0.42) | 231 (0.39) | 307 (0.43) | |
GG | 32 (0.12) | 69 (0.11) | 37 (0.12) | 14 (0.13) | 69 (0.12) | 83 (0.12) | |
Total | 280 | 606 | 308 | 110 | 588 | 716 | |
Allele frequency A/G | 0.62/0.38 | 0.67/0.33 | 0.71/0.29 | 0.66/0.34 | 0.69/0.31 | 0.67/0.33 | |
rs2835761 | CC | 203 (0.70) | 422 (0.69) | 232 (0.72) | 84 (0.75) | 435 (0.71) | 506 (0.70) |
CT | 82 (0.29) | 176 (0.29) | 85 (0.26) | 27 (0.24) | 167 (0.27) | 203 (0.28) | |
TT | 4 (0.01) | 11 (0.02) | 6 (0.02) | 1 (0.01) | 10 (0.02) | 12 (0.02) | |
Total | 289 | 609 | 323 | 112 | 612 | 721 | |
Allele frequency C/T | 0.84/0.16 | 0.84/0.16 | 0.85/0.15 | 0.87/0.13 | 0.85/0.15 | 0.84/0.16 | |
rs2835762 | CC | 216 (0.81) | 467 (0.78) | 243 (0.77) | 82 (0.73) | 459 (0.79) | 549 (0.78) |
CT | 49 (0.18) | 119 (0.20) | 69 (0.22) | 27 (0.24) | 118 (0.20) | 146 (0.21) | |
TT | 3 (0.01) | 9 (0.02) | 4 (0.01) | 3 (0.03) | 7(0.01) | 12 (0.01) | |
Total | 268 | 595 | 316 | 112 | 584 | 707 | |
Allele frequency C/T | 0.90/0.10 | 0.88/0.12 | 0.88/0.12 | 0.85/0.15 | 0.89/0.11 | 0.88/0.12 | |
rs2154545 | GG | 105 (0.37) | 218 (0.36) | 141 (0.43) | 43 (0.38) | 246 (0.40) | 261 (0.36) |
GA | 136 (0.47) | 280 (0.46) | 135 (0.42) | 49 (0.44) | 271 (0.44) | 329 (0.46) | |
AA | 45 (0.16) | 108 (0.18) | 50 (0.15) | 20 (0.18) | 95 (0.16) | 128 (0.18) | |
Total | 286 | 606 | 326 | 112 | 612 | 718 | |
Allele frequency G/A | 0.60/0.40 | 0.59/0.41 | 0.64/0.36 | 0.60/0.40 | 0.62/0.38 | 0.59/0.41 | |
rs8132976 | AA | 95 (0.34) | 194 (0.33) | 93 (0.29) | 33 (0.30) | 188 (0.31) | 227 (0.32) |
AC | 122 (0.43) | 285 (0.48) | 138 (0.43) | 48 (0.43) | 260 (0.43) | 333 (0.47) | |
CC | 66 (0.23) | 116 (0.19) | 91 (0.28) | 30 (0.27) | 157 (0.26) | 146 (0.21) | |
Total | 283 | 595 | 322 | 111 | 605 | 706 | |
Allele frequency A/C | 0.55/0.45 | 0.57/0.43 | 0.50/0.50 | 0.51/0.49 | 0.53/0.47 | 0.56/0.44 |