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Table 3 Genotype distributions and allele frequencies of the three SNPs tested in stage 1 and stage 2

From: Emilin1 gene and essential hypertension: a two-stage association study in northern Han Chinese population

SNP

Group

Genotype

Allele

   

WT

Ht+MT

ORa (95%CI)

Pa

Major/Minor

OR (95%CI)

P

Stage 1

rs3754734

 

TT

TG+GG

  

T/G

  
  

Case

153

261+89

  

0.564/0.436

  
  

Control

188

214+88

1.336(1.013-1.762)

0.040

0.602/0.398

1.17(0.98-1.40)

0.082

 

rs2011616

 

GG

GA+AA

  

G/A

  
  

Case

244

214+43

  

0.701/0.299

  
  

Control

270

181+39

1.348(1.035-1.756)

0.027

0.736/0.264

1.19(0.98-1.45)

0.082

 

rs2304682

 

GG

GC+CC

  

G/C

  
  

Case

245

213+45

  

0.699/0.301

  
  

Control

251

196+43

1.034(0.796-1.343)

0.840

0.712/0.288

1.07(0.88-1.29)

0.511

Stage 2

rs3754734

 

TT

TG+GG

  

T/G

  
  

Case

522

598+164

  

0.648/0.352

  
  

Control

533

570+163

0.980(0.832-1.155)

0.811

0.646/0.354

0.992(0.885-1.112)

0.894

 

rs2011616

 

GG

GA+AA

  

G/A

  
  

Case

643

555+109

  

0.704/0.296

  
  

Control

608

541+110

1.004(0.853-1.181)

0.963

0.698/0.302

1.032 (0.915-1.163)

0.611

  1. a. Adjusted for gender, age, BMI, TC, TG, Cr, HDL-C, LDL-C, Glu, smoking, drinking.
  2. WT wide type, Ht heterozygote, MT mutant type