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Table 2 Comparison of clinical characteristics between cases and controls in stage 1, stage 2 and joint analysis

From: Emilin1 gene and essential hypertension: a two-stage association study in northern Han Chinese population

 

Stage 1

Stage 2

Joint analysis

Characteristics

Cases (n = 503)

Controls (n = 490)

Cases (n = 814)

Controls (n = 779)

Cases (n = 1317)

Controls (n = 1269)

Male (%)

52.1

52.4

48.3

51.5

49.7

51.9

Age (years)

53.6 ± 9.3

53.5 ± 9.2

54.5 ± 10.7

53.5 ± 9.7

54.2 ± 10.2

53.5 ± 9.5

SBP (mmHg)

177.07 ± 28.05*⊿

117.47 ± 11.64⊿

148.98 ± 17.84*

113.81 ± 9.86

159.70 ± 26.13*

115.21 ± 10.72

DBP (mmHg)

104.34 ± 12.28*⊿

75.05 ± 8.00⊿

90.62 ± 9.81*

72.86 ± 7.57

95.85 ± 12.70*

73.69 ± 7.81

BMI (kg/m2)

26.32 ± 3.85*

24.30 ± 3.56

25.79 ± 3.52*

23.85 ± 3.37

26.00 ± 3.67*

24.03 ± 3.43

TC (mg/dl)

198.64 ± 37.50****

192.46 ± 40.06

197.34 ± 35.82*

188.43 ± 38.15

197.84 ± 36.46*

189.98 ± 38.93

HDL-C (mg/dl)

48.80 ± 11.83***

51.31 ± 13.07

48.38 ± 11.14*

49.39 ± 11.43

48.54 ± 11.41**

50.13 ± 12.12

LDL-C (mg/dl)

121.28 ± 32.64****

117.38 ± 32.98

122.08 ± 32.69*

115.81 ± 34.36

121.78 ± 32.66*

116.42 ± 33.83

TG (mg/dl)

150.58 ± 94.21*

126.62 ± 76.42

134.94 ± 65.09*

116.67 ± 55.37

140.92 ± 77.85*

120.51 ± 64.47

Glu (mg/dl)

106.77 ± 32.40*

99.09 ± 18.77

97.28 ± 10.90*

94.80 ± 11.55

100.90 ± 22.25*

96.46 ± 14.91

Cr (μmol/l)

70.83 ± 15.21****

68.92 ± 12.12

70.92 ± 13.34

71.03 ± 12.93

70.89 ± 14.08

70.21 ± 12.66

Smokers (%)

40.6

43.1

39.7

43.0

40.0

43.0

Drinkers (%)

34.4

33.5

30.1

28.4

31.7

30.3

Anti-hypertensive medication (%)

33.00

 

35.14

 

34.32

 
  1. *P < 0.0001 for comparison with corresponding controls
  2. **P < 0.001 for comparison with corresponding controls
  3. ***P < 0.01 for comparison with corresponding controls
  4. ****P < 0.05 for comparison with corresponding controls
  5. ⊿ P < 0.0001 for comparison with corresponding variables in stage 2