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Table 3 Regression analysis in European samples for all SNPs in selected subtypes.

From: Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma

 

Controls

 

DLBCL

  

FL

  

MZ/MALT

 

SNP

N

N

OR (95% CI)

p value

N

OR (95% CI)

p value

N

OR (95% CI)

p value

RAD50_IVS4(+19)G/A

          

G/G

384

100

1

0.896

107

1

0.474

43

1

-

G/A

187

53

1.05 (0.72 - 1.54)

0.799

55

1.08 (0.74 - 1.58)

0.677

19

1.01 (0.57 - 1.80)

0.975

A/A

27

7

0.96 (0.40 - 2.30)

0.935

10

1.31 (0.61 - 2.81)

0.492

3

1.03 (0.29 - 3.61)

0.966

G/A & A/A

214

      

22

1.01 (0.58 - 1.76)

0.967

RAD50_IVS7(-38)C/T

          

C/C

568

153

1

-

166

1

-

58

1

-

C/T

34

9

1.01 (0.47 - 2.17)

0.983

6

0.63 (0.26 - 1.53)

0.304

8

3.02 (1.28 - 7.14)

0.012

T/T

1

0

0.00 (0.00 -)

1.000

1

3.41 (0.21 - 56.13)

0.391

1

24.77 (1.43 - 427.94)

0.027

C/T & T/T

35

9

0.97 (0.45 - 2.08)

0.941

7

0.71 (0.31 - 1.64)

 

9

3.39 (1.48 - 7.75)

0.004

RAD50_IVS22(+24)A/G

          

A/A

546

137

1

-

150

1

-

59

1

-

A/G

54

25

1.77 (1.05 - 2.96)

0.031

24

1.61 (0.96 - 2.71)

0.073

7

1.30 (0.55 - 3.04)

0.550

G/G

1

1

4.54 (0.26 - 78.43)

0.298

0

0.00 (0.00 -)

1.000

0

0.00 (0.00 -)

1.000

A/G & G/G

55

26

1.81 (1.09 - 3.01)

0.022

24

1.59 (0.94 - 2.67)

0.081

7

1.29 (0.55 - 3.02)

0.560

RAD50_IVS22(+62)A/G

          

A/A

601

161

-

-

174

-

-

67

-

-

A/G

2

2

-

-

0

-

-

0

-

-

G/G

0

0

-

-

0

-

-

0

-

-

NBS1_5(-905)T/C

          

T/T

266

76

1

0.465

87

1

0.847

28

1

0.816

T/C

267

72

0.95 (0.66 - 1.37)

0.769

63

0.75 (0.51 - 1.08)

0.119

43

1.12 (0.65 - 1.93)

0.678

C/C

64

14

0.77 (0.41 - 1.46)

0.423

24

1.20 (0.70 - 2.06)

0.498

7

1.02 (0.42 - 2.48)

0.964

NBS1_5UTR_(-352)_del(AGTA)

          

AGTA/AGTA

524

138

1

-

137

1

-

60

1

-

AGTA/-

58

16

1.06 (0.59 - 1.92)

0.839

18

1.08 (0.61 - 1.92)

0.785

2

0.30 (0.07 - 1.29)

0.105

-/-

2

0

0.00 (0.00 -)

0.999

3

5.57 (0.90 - 34.52)

0.065

0

0.00 (0.00 -)

0.999

AGTA/- & -/-

60

16

1.03 (0.57 - 1.85)

0.929

21

1.23 (0.71 - 2.11)

0.461

2

-

-

NBS1_IVS3(+208)G/A

          

G/G

241

66

1

0.672

84

1

0.466

26

1

0.818

G/A

277

76

1.00 (0.68 - 1.45)

0.977

63

0.67 (0.46 - 0.97)

0.033

30

0.97 (0.56 - 1.71)

0.935

A/A

78

19

0.86 (0.48 - 1.52)

0.596

27

1.04 (0.62 - 1.72)

0.892

10

1.14 (0.52 - 2.51)

0.744

NBS1_3UTR(+273)G/A

          

G/G

268

78

1

0.256

90

1

0.509

26

1

0.807

G/A

263

73

0.97 (0.68 - 1.40)

0.885

54

0.65 (0.44 - 0.95)

0.026

33

1.28 (0.74 - 2.23)

0.381

A/A

63

11

0.60 (0.24 - 1.19)

0.142

24

1.12 (0.66 - 1.91)

0.669

6

0.89 (0.35 - 2.29)

0.813

NBS1_X2_(102)_G/A

          

G/G

266

75

1

0.521

87

1

0.935

28

1

0.698

G/A

272

72

0.95 (0.66 - 1.37)

0.782

62

0.72 (0.50 - 1.04)

0.082

33

1.15 (0.67 - 1.97)

0.615

A/A

59

13

0.79 (0.41 - 1.53)

0.486

24

1.31 (0.76 - 2.25)

0.326

7

1.09 (0.45 - 2.67)

0.849

NBS1_X5_(553)_G/C

          

G/G

255

76

1

0.306

84

1

0.786

28

1

0.938

G/C

270

72

0.90 (0.62 - 1.30)

0.572

62

0.73 (0.50 - 1.06)

0.098

33

1.12 (0.65 - 1.92)

0.688

C/C

57

12

0.70 (0.36 - 1.39)

0.310

22

1.22 (0.70 - 2.13)

0.486

6

0.92 (0.36 - 2.36)

0.857

NBS1_X13_(2016)_A/G

          

A/A

247

74

1

0.204

83

1

0.634

27

1

0.897

A/G

265

70

0.89 (0.61 - 1.30)

0.549

59

0.69 (0.47 - 1.01)

0.055

33

1.13 (0.65 - 1.95)

0.671

G/G

55

10

0.61 (0.29 - 1.26)

0.180

21

1.20 (0.68 - 2.12)

0.537

6

0.94 (0.36 - 2.43)

0.902

MRE11_5(-1703)A/G

          

A/A

261

76

1

0.431

81

1

0.725

25

1

0.100

A/G

267

60

0.91 (0.63 - 1.32)

0.629

69

0.84 (0.58 - 1.21)

0.341

29

1.20 (0.68 - 2.13)

0.527

G/G

66

15

0.79 (0.42 - 1.47)

0.457

22

1.03 (0.59 - 1.78)

0.919

13

1.95 (0.93 - 4.10)

0.076

MRE11_5(-1456)C/T

          

C/C

582

153

1

-

165

1

-

67

-

-

C/T

21

9

1.76 (0.78 - 3.96)

0.173

9

1.38 (0.61 - 3.09)

0.441

1

-

-

T/T

1

1

4.32 (0.26 - 72.48)

0.309

0

0.00 (0.00 -)

0.100

0

-

-

C/T & T/T

22

10

1.87 (0.86 - 4.08)

0.115

9

1.34 (0.60 - 2.99)

0.481

   

MRE11_IVS2(+28)G/A

          

G/G

189

51

1

0.751

54

1

0.967

17

1

0.144

G/A

277

81

1.07 (0.72 - 1.59)

0.753

85

1.10 (0.75 - 1.63)

0.623

32

1.42 (0.75 - 2.66)

0.279

A/A

124

30

0.90 (0.54 - 1.49)

0.675

34

0.99 (0.61 - 1.61)

0.959

18

1.69 (0.83 - 3.46)

0.150

MRE11_IVS9(-60)A/T

          

T/T

270

82

1

0.419

77

1

0.866

27

1

0.625

T/A

255

61

0.75 (0.51 - 1.09)

0.130

79

1.15 (0.80 - 1.66)

0.453

29

1.19 (0.68 - 2.11)

0.542

A/A

70

20

0.96 (0.55 - 1.68)

0.877

17

0.82 (0.45 - 1.47)

0.498

9

1.14 (0.51 - 2.58)

0.752

BLM_IVS7(+388)C/T

          

C/C

517

140

1

-

148

1

-

62

1

-

C/T

78

22

1.04 (0.62 - 1.73)

0.891

24

1.03 (0.63 - 1.70)

0.908

6

0.62 (0.26 - 1.49)

0.284

T/T

3

0

0.00 (0.00 -)

0.999

1

0.96 (0.10 - 9.65)

0.970

0

0.00 (0.00 -)

0.999

C/T & T/T

81

22

1.01 (0.60 - 1.68)

0.978

25

1.03 (0.623- 1.68)

0.915

6

0.59 (0.25 - 1.43)

0.244

BLM_IVS7(+798)ins(T)

          

T/T

528

145

1

-

156

1

-

62

1

-

T/-

69

17

0.89 (0.51 - 1.57)

0.689

17

0.90 (0.51 - 1.58)

0.702

5

0.71 (0.27 - 1.84)

0.474

-/-

4

0

0.00 (0.00 -)

0.999

1

1.09 (0.12 - 10.39)

0.939

0

0.00 (0.00 -)

0.999

T/- & -/-

73

17

0.84 (0.48 - 1.47)

0.534

18

0.90 (0.52 - 1.58)

0.722

5

0.67 (0.26 - 1.75)

0.418

BLM_IVS12(+7)T/C

          

T/T

316

88

1

0.944

88

1

0.696

33

1

0.609

T/C

243

58

0.85 (0.58 - 1.23)

0.389

68

0.99 (0.69 - 1.43)

0.975

29

1.18 (0.69 - 2.02)

0.546

C/C

45

15

1.23 (0.55 - 2.32)

0.533

16

1.21 (0.65 - 2.26)

0.554

5

1.12 (0.41 - 3.07)

0.823

BLM_IVS21(-60)_del(GAA)

          

GAA/GAA

237

61

1

0.968

74

1

0.727

37

1

0.026

GAA/-

283

81

1.09 (0.75 - 1.60)

0.640

75

0.87 (0.60 - 1.26)

0.452

21

0.46(0.26 - 0.82)

0.008

-/-

76

19

0.94 (0.53 - 1.69)

0.840

24

0.98 (0.58 - 1.68)

0.949

8

0.56 (0.24 - 1.27)

0.162

  1. OR = Odds Ratio, CI = Confidence Interval, DLBCL = Diffuse Large B-Cell Lymphoma, FL = Follicular Lymphoma, MZ/MALT = Marginal Zone lymphoma/Mucosa-Associated Lymphoma Tissue lymphoma.
  2. If less than 5 samples were in a category, the analysis is not valid and marked by "-". Analyses were not done for subtypes that had fewer than 5 heterozygotes and minor homozygotes combined. Analysis is adjusted for adjusted for gender, ethnicity, age, and residence.
  3. p-value for test for trend is shown in italic type.
  4. p-values less than 0.05 are in bold.
  5. All results are in Additional file 9.