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Table 3 Risk of COPD in smokers and PLAUR SNPs

From: PLAURpolymorphisms and lung function in UK smokers

 

Controls

(n = 176)

COPD

(n = 599)

Additive

Recessive

Dominant

SNP

0

1

2

0

1

2

p-value

Odds ratio

95%CI

p-value

Odds ratio

95%CI

p-value

Odds ratio

95%CI

rs4803648

112

48

9

381

180

21

0.963

1.01

0.70-1.45

0.313

0.60

0.23-1.61

0.637

1.11

0.72-1.70

rs4802189

117

47

4

420

151

12

0.964

0.99

0.66-1.48

0.735

0.79

0.20-3.13

0.955

1.01

0.65-1.59

rs4251953

158

15

1

540

43

2

0.800

0.92

0.49-1.74

0.825

1.38

0.08-24.45

0.742

0.89

0.45-1.77

rs4251938

133

38

1

466

116

8

0.969

0.99

0.63-1.56

0.656

1.70

0.17-17.27

0.883

0.96

0.59-1.57

rs4251923

166

8

0

544

44

0

0.598

1.28

0.52-3.16

ND

ND

ND

0.598

1.28

0.52-3.16

rs4760

122

38

10

429

146

13

0.271

0.81

0.56-1.18

0.106

0.42

0.15-1.20

0.523

0.86

0.55-1.36

rs2302524

121

54

1

422

149

16

0.691

0.92

0.63-1.37

0.081

7.23

0.78-66.86

0.293

0.79

0.51-1.22

rs4251864

143

30

1

507

81

5

0.976

1.01

0.61-1.66

0.480

2.38

0.22-26.30

0.876

0.96

0.56-1.64

rs2239372

48

84

41

150

284

156

0.679

1.06

0.80-1.40

0.857

1.04

0.66-1.66

0.621

1.12

0.71-1.76

rs2283628

122

43

10

396

172

23

0.822

0.96

0.67-1.38

0.118

0.47

0.18-1.21

0.706

1.09

0.71-1.67

rs4251846

141

31

3

452

134

8

0.518

1.16

0.74-1.82

0.380

0.50

0.11-2.34

0.340

1.27

0.78-2.08

rs2239374

115

57

4

401

173

15

0.379

0.85

0.59-1.23

0.785

0.84

0.25-2.88

0.369

0.83

0.54-1.26

rs2286960

91

71

13

347

215

30

0.022

0.68

0.49-0.95

0.049

0.45

0.20-0.99

0.061

0.68

0.45-1.02

rs4251805

163

11

0

538

46

1

0.323

1.49

0.68-3.30

ND

ND

ND

0.340

1.48

0.66-3.30

rs344781

110

50

13

358

191

33

0.719

1.06

0.76-1.49

0.729

0.86

0.38-1.97

0.534

1.14

0.75-1.74

rs2356338

90

69

16

282

271

38

0.397

1.15

0.83-1.60

0.685

0.85

0.39-1.86

0.215

1.29

0.86-1.92

rs344780

107

42

11

341

180

31

0.611

1.10

0.77-1.56

0.729

0.86

0.36-2.06

0.422

1.197

0.77-1.86

rs344779

65

78

33

229

287

74

0.097

0.78

0.58-1.05

0.029

0.54

0.31-0.94

0.437

0.85

0.57-1.28

rs8113334

120

47

9

397

172

24

0.969

1.01

0.71-1.44

0.478

0.71

0.27-1.85

0.729

1.08

0.70-1.66

rs4493171

114

53

7

348

215

28

0.204

1.26

0.88-1.79

0.768

1.16

0.44-3.09

0.165

1.34

0.89-2.04

rs7259340

70

77

26

251

263

69

0.147

0.80

0.60-1.08

0.155

0.65

0.36-1.18

0.299

0.81

0.54-1.21

rs11668247 

67

68

41

241

267

87

0.034

0.74

0.56-0.98

0.022

0.55

0.34-0.92

0.172

0.75

0.50-1.13

rs346043

94

66

12

305

251

36

0.279

1.20

0.86-1.67

0.836

1.09

0.48-2.48

0.221

1.28

0.86-1.92

rs740587

54

72

50

206

272

110

0.010

0.70

0.53-0.92

0.016

0.56

0.35-0.90

0.056

0.66

0.43-1.01

rs346054

59

69

48

171

296

124

0.293

0.86

0.66-1.14

0.011

0.55

0.35-0.87

0.509

1.15

0.76-1.77

  1. 0, 1, 2 represent number of genotypes for major, heterozygote and minor genotypes respectively. For minor allele frequencies in controls versus COPD cases see Table 2. Logistic regression was used to compare genotype frequencies using the additive, recessive, and dominant models with covariates age, sex and pack years included in the model. ND = Not determined (minor allele frequency too low).