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Table 1 Baseline Characteristic of the Study Population and Subpopulations

From: Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis

 

All

LCAS

TexGen

p

N

784

333

451

---

Demographics

Age (years)

59.3 ± 11.0

59.3 ± 7.7

59.2 ± 13.2

0.527

Male/Female (%)

586/198 (75/25)

281/52 (84/16)

305/146 (68/32)

<0.001

Height (m)

1.73 ± 0.09

1.74 ± 0.08

1.73 ± 0.10

0.328

Body weight (Kg)

86.8 ± 18.8

84.9 ± 15.6

88.3 ± 20.7

0.006

Body mass index (Kg/m2)

28.8 ± 5.5

28.1 ± 4.5

29.3 ± 6.1

0.001

Systolic blood pressure (mmHg)

125.9 ± 19.3

124.5 ± 15.3

127.1 ± 21.8

0.029

Diastolic blood Pressure (mmHg)

75.8 ± 11.9

76.7 ± 8.8

75.1 ± 13.7

0.028

Diabetes mellitus (%)

117 (14.5)

11 (3.3)

106 (23.5)

<0.001

Smoker (%)

137 (17.5)

68 (20)

69 (15)

0.071

History of myocardial infarction (%)

289 (36.9)

131 (39)

158 (35)

<0.001

Plasma Lipids levels

TC (mg/dl)

200.1 ± 56.5

220.0 ± 24.5

185.2 ± 68.0

<0.001

HDL-C (mg/dl)

43.8 ± 13.9

43.8 ± 11.3

43.8 ± 15.5

0.671

LDL-C (mg/dl)

123.9 ± 46.9

143.9 ± 19.9

107.5 ± 55.1

<0.001

LDL-C/HDL-C

3.02 ± 1.28

3.49 ± 0.91

2.65 ± 1.40

<0.001

Triglyceride (mg/dl)

169.7 ± 154.8

161.5 ± 57.1

175.8 ± 198.0

0.101

Plasma apolipoprotein levels (LCAS only)

N

 

333

  

Apolipoprotein A-I

 

132.7 ± 27.4

  

Apolioprotein B

 

134.4 ± 20.8

  

Apolipoprotein B/Apolioprotein A-I

 

1.05 ± 0.26

  

Apolipoprotein C-III

 

35.2 ± 32.8

  

Quantitative indices of severity of coronary atherolosclerosis (LCAS only)

N

 

289

  

Average baseline MLD (mm)

 

1.68 ± 0.40

  

Mean number of coronary lesions

 

2.99 ± 1.38

  

Number of subject with ≥ two coronary lesion (%)

 

241 (83%)

  

Mean number of coronary occlusions

 

0.29 ± 0.55

  

Number of subject with ≥ one coronary

 

72 (25%)

  
  1. Abbreviations: m: meter; Kg: Kilogram; mmHg: millimeter mercury; mg/dl: milligram per deciliter; TC: Total cholesterol; HDL-C: High-density lipoprotein-cholesterol; LDL-C: low-density lipoprotein-cholesterol; MLD: minimal lumen diameter.